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Systematic Review · Vol. 1, Issue 1

Personalized microbiome biotherapeutics across recurrent CDI, cancer immunotherapy, ulcerative colitis and MDRO decolonization: a PRISMA 2020 systematic review with structured narrative synthesis

Microbiome biotherapeutics range from standardized indication-specific products to donor-, recipient- and ecology-informed interventions.

personalized microbiome medicinemicrobiome biotherapeuticsfecal microbiota transplantationdonor-recipient matchingmetagenomicsmetabolomics

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Systematic Review · Vol. 1, Issue 1

Personalization of contemporary incretin therapy for obesity: a focused systematic review

Contemporary incretin-based therapy has shifted obesity management from ranking drugs by mean weight loss alone toward selection based on dominant comorbidity, treatment persistence, route preference, tolerability, body composition, and the consequences of withdrawal.

obesityGLP-1tirzepatidesemaglutidepersonalized medicinePRISMA 2020

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Evidence Map · Vol. 1, Issue 1

Multimodal and Generative AI-Enabled Clinical Decision Support in Medicine: A PRISMA 2020-Informed Evidence Map and Narrative Synthesis

Multimodal and generative AI systems are increasingly proposed for clinical decision support, but the literature ranges from pragmatic trials to simulated consultations and benchmark-like evaluations.

multimodal artificial intelligencevision-language modelsgenerative AIclinical decision supporthuman-in-the-loopexternal validation

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Systematic Review · Vol. 1, Issue 1

Circulating Tumor DNA for Molecular Residual Disease Detection and Multicancer Early Detection: A Systematic Review

Circulating tumor DNA is clinically advanced in oncology, but its value differs between molecular residual disease assessment after curative-intent treatment and multicancer early detection in asymptomatic populations.

circulating tumor DNActDNAliquid biopsymolecular residual diseasemulticancer early detectionMCED

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Systematic Review · Vol. 1, Issue 1

Personalized Phage Therapy for Drug-Resistant and Difficult-to-Treat Bacterial Infections: A Systematic Review of Human Clinical Evidence and Narrative Synthesis

Personalized bacteriophage therapy selects, adapts, or engineers a phage preparation against a patient clinical isolate. This biological specificity may improve target engagement but complicates standardization and causal inference.

bacteriophage therapypersonalized phage therapyantimicrobial resistancemultidrug resistancephage susceptibility testingantiphage immunity

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